{"product_id":"biolegend-683202","title":"Biolegend, 683202, Purified anti-CCL11 Antibody, 500μg","description":"\u003cp\u003eCCL11 is a member of the CC chemokine family. It was originally identified as a chemoattractant for eosinophils, and participates in a variety of allergic responses to allergens. CCL11 induces angiogenic responses in CCR3 + microvascular endothelial cells and facilitates the proliferation and metastasis of CCR3 + tumor cells.\u003cbr\u003e\n500μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant Mouse CCL11, (amino acids (His24-Pro97, Accession# NM_011330), were expressed in E. coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ELISA Capture - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by ELISA. For ELISA capture applications, a concentration of 0.5 µg\/mL is recommended. To obtain a linear standard curve, serial dilutions of CCL11 recombinant protein ranging from 500 to 7.81 pg\/mL are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance.\u003cbr\u003e\nRRID: AB_2686953 (BioLegend Cat. No. 683202)\u003cbr\u003e\nStructure: Chemokine\u003cbr\u003e\nDistribution: Epithelial cells, smooth muscle cells, dendritic cells, fibroblasts, mast cells, and Th2 lymphocytes.\u003cbr\u003e\nFunction: Recruits eosinophils in allergic responses. Stimulates eosinophil release from bone marrow, increasing levels of circulating eosinophils. Induced by pro-inflammatory cytokines (IL-4, IL-13, TNF-7alpha;, and IFN-α).\u003cbr\u003e\nInteraction: Eosinophils\u003cbr\u003e\nLigand\/Receptor: CCR3\u003cbr\u003e\nCell Type: Epithelial cells, Dendritic cells, Fibroblasts, Mast cells, Th2, Eosinophils\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Immunology, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Crump MP, et al. 1998. J. Biol. Chem. 273:22471. 2. Conroy DM, et al. 2001. Respir. Res. 2:150. 3. Salcedo R, et al. 2001. J. Immunol. 166:7571. 4. Hadjicharalambous C, et al. 2004. J. Allergy Clin. Immunol. 113:657. 5. Kaehler J, et al. 2006. J. Investig. Med. 54:446. 6. Levina V, et al. 2009. Clin. Cancer Res. 15:2647.\u003cbr\u003e\nGene ID: 20292\u003cbr\u003e\nUniProt: View information about CCL11 on UniProt.org\u003cbr\u003e\nClone: L403H11\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Eotaxin, eotaxin-1, small inducible cytokine subfamily A, member 11 (SCYA11)\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866123129001,"sku":"683202","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-683202","provider":"Iright","version":"1.0","type":"link"}