{"product_id":"biolegend-694405","title":"Biolegend, 694405, Biotin anti-human CCL22 Antibody, 50μg","description":"\u003cp\u003eCCL22 is thymus-specific chemokine engaged in the recruitment of T cells. CCL22 is associated with different diseases such as allergen-induced lung inflammation, atopic dermatitis, and lymphoma. Also, high levels of CCL22 have been detected in the CNS in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). In addition, CCR4+ T cells have been linked to endotoxic shock, rheumatoid arthritis, T cell lymphoma, and autoimmune diabetes. CCL22 is a prostaglandin-dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human CCL22\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: Direct ELISA - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Direct ELISA. The optimal concentration of this reagent for the specific application and the experiment design should be established by the end-user.\u003cbr\u003e\nApplication Notes: Clones A15083A and A15083D do not block each other Clone A15083A does not block the reference clone T51-719 (BD Bioscience) Clones A15083A and A15083D showed good staining in both Cyto-Fast™ Fix\/Perm Buffer Set and True-Phos™ Perm Buffer.\u003cbr\u003e\nAdditional Product Notes: This product is intended for sandwich-based immunoassay development on various assay platforms requiring antibody pairs. This antibody (clone A152083D) could function as a detection antibody when paired with purified anti-human CCL22 (MDC) antibody (Cat. No. 611952) (clone A15083A) as the capture antibody and using Recombinant Human CCL22 (MDC) (carrier-free) protein (Cat. Nos. 584902 and 584904) as the assay standard.\u003cbr\u003e\nRRID: AB_3097162 (BioLegend Cat. No. 694405)\u003cbr\u003e\nStructure: Chemokine\u003cbr\u003e\nDistribution: Macrophages, NK cells, IFN-γ stimulated human keratinocytes, thymic epithelial cells, and intestinal epithelial cells\u003cbr\u003e\nFunction: CCL22 induces the migration of CCR4+ Th2 cells, Tregs, DC, and NK cells. It is induced by LPS and CD40 antibody in macrophages. It is upregulated by Th2 cytokines (IL-4 and IL-5) and downregulated by Th1 cytokines (IFN-γ).\u003cbr\u003e\nInteraction: Dendritic cells, NK cells, Th2 cells, T regs, CLA+ skin-homing memory\/effector T cells\u003cbr\u003e\nLigand\/Receptor: CCR4\u003cbr\u003e\nBiology Area: Cell Biology, Signal Transduction\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: Godiska R, et al. 1997. J Exp Med. 185:1595-604. Imai T, et al. 1998. J Biol Chem. 273:16551-4. Yamashita U and Kuroda E. 2002. Crit Rev Immunol. 22:105-14. Horikawa T, et al. 2002. Int Immunol. 14:767-73. Mailloux AW and Young MR. 2009. J Immunol. 182:2753-65. Dogan RN, et al. 2011. J Leukoc Biol. 89:93-104. Osborn O, et al. 2011. Cytokine. 53:311-9.\u003cbr\u003e\nGene ID: 6367\u003cbr\u003e\nUniProt: View information about CCL22 on UniProt.org\u003cbr\u003e\nClone: A15083D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Macrophage derived cytokine (MDC), Small inducible cytokine subfamily A, member 22 (Scya22), stimulated T cell chemotactic protein (STCP-1)\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864385310889,"sku":"694405","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-694405","provider":"Iright","version":"1.0","type":"link"}