{"product_id":"biolegend-695602","title":"Biolegend, 695602, Purified anti-BACH2 Antibody, 100μg","description":"\u003cp\u003eBTB and CNC Homolog 2 (BACH2) is a transcription factor of the basic leucine zipper family. BACH2 participates in the regulation of both innate and adaptive immune responses. In B cells, BACH2 plays critical roles in somatic hypermutation, class-switch recombination, memory B cell formation, and repression of myeloid genes. In T cells, BACH2 promotes the development of Foxp3+ regulatory T cells and memory T cells. Bach2 is required for the maintenance of naive CD4 T cells by suppressing effector T cell differentiation. BACH2 is also required for the maturation and function of alveolar macrophages. Defects in BACH2 gene are associated with autoimmune and allergic diseases, such as asthma, type 1 diabetes, celiac disease, rheumatoid arthritis, and generalized vitiligo.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human BACH2 recombinant protein (513-841 a.a.) expressed in E. coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2650879 (BioLegend Cat. No. 695602)\u003cbr\u003e\nStructure: 841 amino acids with a predicted molecular weight of 92.5 kD. Contains a N-terminal BTB\/POZ domain for protein-protein interaction and a C-terminal bZIP domain for DNA binding.\u003cbr\u003e\nDistribution: Nucleus and cytoplasm.\u003cbr\u003e\nFunction: BACH2 is a transcription factor involved in the development and differentiation of both B and T cells.\u003cbr\u003e\nInteraction: Forms homodimers or heterodimers with Maf-related transcription factors.\u003cbr\u003e\nCell Type: B cells, Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Transcription Factors\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: 1. Kuwahara M, et al. 2016. Nat. Commun. 7:12596. 2. Sidwell T, et al. 2016. Nat. Immunol. 17:744. 3. Roychoudhuri R, et al. 2016. Nat. Immunol. 17:851. 4. Itoh-Nakadai A, et al. 2014. Nat. Immunol. 15:1171. 5. Kuwahara M, et al. 2014. Nat. Commun. 5:3555. 6. Kim EH, et al. 2014. J. Immunol. 192:985.\u003cbr\u003e\nGene ID: 60468\u003cbr\u003e\nUniProt: View information about BACH2 on UniProt.org\u003cbr\u003e\nClone: 16B10B53\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: BTB and CNC homolog 2, Transcription regulator protein BACH2,\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864358244521,"sku":"695602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-695602","provider":"Iright","version":"1.0","type":"link"}