{"product_id":"biolegend-803403","title":"Biolegend, 803403, Purified anti-Apo E Antibody (Previously Covance catalog# SIG-39750), 1ml","description":"\u003cp\u003eApo-E is a class of apolipoprotein primarily synthesized in the liver, but is also found in other tissues such as brain, kidneys, and spleen. Apo-E is a protein component of serum chylomicron and lipoprotein particles, playing essential roles in cholesterol transportation, homeostasis, and metabolism. The expression of Apo-E is induced by cholesterol-rich diets and hyperlipoproteinemia. In the central nervous system, Apo-E is produced by astrocytes and microglia. The Apo-E-containing lipoprotein particles play important functions in brain injury repair, neurogenesis, and synaptic plasticity. Apo-E has been found to be involved in the regulation of amyloid-β aggregation and clearance. Genetic polymorphisms of Apo-E are associated with neuron degenerative disorders including Alzheimer's disease.\u003cbr\u003e\n1ml\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: This antibody was raised against a synthetic peptide corresponding to amino acids surrounding the polymorphic amino acid position 158 of Apo-E.\u003cbr\u003e\nFormulation: Phosphate-buffered solution (no preservatives or carrier proteins).\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 1 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg\/ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This antibody is effective in immunoblotting (WB).Clone E6D7 recognizes the E2, E3, and E4 isoforms of apolipoprotein E.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Munoz DG, Feldman H. 2000. CMAJ. 162(1):65-72. Hagberg JM, et al. 2000. Physiol Genomics 4(2):101-108. Saunders AM. 2000. J. Neuropathol. Exp. Neurol. 59(9):751-8. Golabek AA, et al. 2000. Biophys. J. 79(2):1008-15. Zunarelli E, et al. 2000. Breast Cancer Res. Treat. 63(3):193-8. Zunarelli E, et al. 2000. Clin. Neuropathol. 19(1):1-6. Tomiyama T, et al. 1999. Cell Mol. Life Sci. 56(3-4):268-79. Golabek AA., et al. 1999. J. Biol. Chem. 271(18):10602-6.\u003cbr\u003e\nRRID: AB_2564664 (BioLegend Cat. No. 803401) AB_2564663 (BioLegend Cat. No. 803403)\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance\u003cbr\u003e\nMolecular Family: Apolipoproteins\u003cbr\u003e\nGene ID: 348\u003cbr\u003e\nUniProt: View information about Apo E on UniProt.org\u003cbr\u003e\nClone: E6D7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Apolipoprotein E, apolipoprotein E3, AD2, LDLCQ5, LPG, ApoE\u003cbr\u003e\nPreviously: Signet Catalog# 9750-02Signet Catalog# 9750-05Signet Catalog# 9750-10Covance Catalog# SIG-39750\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46863066497193,"sku":"803403","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-803403","provider":"Iright","version":"1.0","type":"link"}