{"product_id":"biolegend-805607","title":"Biolegend, 805607, Purified anti-β-Amyloid, 1-43 Antibody (Previously Covance catalog# SIG-39143), 50microl","description":"\u003cp\u003eAmyloid beta (Aβ or Amyloid beta) denotes peptides of 36-43 amino acids in length that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is cut by certain enzymes to yield Aβ. Aβ molecules can aggregate to form oligomers (known as \"seeds\") which are believed to be able to induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The seeds or the resulting amyloid plaques are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.\u003cbr\u003e\n50microl\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution (no preservatives or carrier proteins).\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.\u003cbr\u003e\nApplication: IHC-P - Quality tested WB - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This antibody is reactive to the C-terminus of beta amyloid and is specific for the isoform ending at the 43rd amino acid. Additional reported applications (for the relevant formats) include: Western blotting (WB)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Takami M, et al. 2009. J. Neurosci. 41:13042. (WB) PubMed\u003cbr\u003e\nProduct Citations: Tan Z 2022. Acta Neuropathologica Communications. 10(1):182. PubMed Willumsen N, et al. 2023. Brain Commun. 5:fcac321. PubMed Takami M, et al. 2009. J Neurosci. 29:13042-13052. PubMed\u003cbr\u003e\nRRID: AB_2750038 (BioLegend Cat. No. 805607) AB_2564686 (BioLegend Cat. No. 805601)\u003cbr\u003e\nCell Type: Embryonic Stem Cells\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation, Stem Cells\u003cbr\u003e\nMolecular Family: APP\/β-Amyloid\u003cbr\u003e\nGene ID: 351\u003cbr\u003e\nUniProt: View information about beta-Amyloid 1-43 on UniProt.org\u003cbr\u003e\nClone: 9C4\/Amyloid\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein\u003cbr\u003e\nPreviously: Signet Catalog# 9143-02Signet Catalog# 9143-05Signet Catalog# 9143-10Covance Catalog# SIG-39143\u003cbr\u003e\nIsotype: Mouse IgG1\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862505803945,"sku":"805607","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-805607","provider":"Iright","version":"1.0","type":"link"}