{"product_id":"biolegend-818008","title":"Biolegend, 818008, Alexa Fluor® 647 anti-Tyrosine Hydroxylase Antibody, 100μg","description":"\u003cp\u003eTyrosine hydroxylase, also known as tyrosine 3-monooxygenase, is the enzyme that converts amino acid L-Tyrosine to L-3, 4-Dihydroxyphenylalanine (L-DOPA).  L-DOPA is a precursor to dopamine, which is then converted to norepinephrine and epinephrine (adrenaline).  Dopamine, norepinephrine and epinephrine are all important neurotransmitters.  Alterations in the activity of tyrosine hydroxylase may be involved in a number of neurological diseases such as Parkinson's and schizophrenia.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: This monoclonal antibody was raised against purified Tyrosine Hydroxylase from rat Pheochromocytoma tumor.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.2 - 5 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: This antibody is effective in immunoblotting (WB) and formalin-fixed paraffin-embedded immunohistochemical staining (IHC-P).This antibody is less reactive in human tissue in Western Blot.\u003cbr\u003e\nProduct Citations: Matryba P, et al. 2020. J Biophotonics. 13:e202000072. PubMed Wang Y, et al. 2022. Nature. 609:569. PubMed\u003cbr\u003e\nRRID: AB_2801154 (BioLegend Cat. No. 818007) AB_2801155 (BioLegend Cat. No. 818008)\u003cbr\u003e\nStructure: Expected MW: 65 kD\u003cbr\u003e\nCell Type: Dopaminergic Neurons, Neural Stem Cells, Neurons\u003cbr\u003e\nBiology Area: Cell Biology, Neuroscience, Neuroscience Cell Markers, Stem Cells, Synaptic Biology\u003cbr\u003e\nMolecular Family: Enzymes and Regulators, Presynaptic proteins\u003cbr\u003e\nGene ID: 25085\u003cbr\u003e\nUniProt: View information about Tyrosine Hydroxylase on UniProt.org\u003cbr\u003e\nClone: 2\/40\/15\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Tyrosine 3-monooxygenase, tyrosine 3-hydroxylase\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860864061609,"sku":"818008","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-818008","provider":"Iright","version":"1.0","type":"link"}