{"product_id":"biolegend-859901","title":"Biolegend, 859901, Purified anti-MOG Antibody, 25μg","description":"\u003cp\u003eMyelin Oligodendrocyte Glycoprotein (MOG) is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. It is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication, and mediate homophilic cell-cell adhesion. Diseases associated with MOG include Narcolepsy 7 and Rubella. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. MOG may also act as a receptor for rubella virus during microbial infection.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Polyclonal\u003cbr\u003e\nHost Species: Rabbit\u003cbr\u003e\nImmunogen: Recombinant MOG expressed in E.coli.\u003cbr\u003e\nFormulation: 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 µg per mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Schindler CR, et al. 2024. Front Immunol. 1347767:15. PubMed\u003cbr\u003e\nRRID: AB_2810735 (BioLegend Cat. No. 859901)\u003cbr\u003e\nStructure: MOG is a 247 amino acid protein with an apparent molecular mass of ~28 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Brain and spinal cord Cellular Distribution: Plasma membrane\u003cbr\u003e\nFunction: MOG is involved in completion and maintenance of the myelin sheath and cell-cell communication.\u003cbr\u003e\nInteraction: Myelin, Rubella virus\u003cbr\u003e\nCell Type: Neurons, Oligodendrocytes\u003cbr\u003e\nBiology Area: Cell Adhesion, Immunology, Neurodegeneration, Neuroscience, Stem Cells\u003cbr\u003e\nMolecular Family: Adhesion Molecules, Innate Immune Signaling\u003cbr\u003e\nAntigen References: Reindl M, et al. 2017. Curr Opin Neurol. 30(3):295. Hennes EM, et al. 2018. Neuropediatrics. 49(1):3.\u003cbr\u003e\nGene ID: 43401744124558\u003cbr\u003e\nUniProt: View information about MOG on UniProt.org\u003cbr\u003e\nClone: Poly28599\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: MOG, Myelin Oligodendrocyte Glycoprotein\u003cbr\u003e\nIsotype: Rabbit Polyclonal IgG\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866466537641,"sku":"859901","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-859901","provider":"Iright","version":"1.0","type":"link"}