{"product_id":"biolegend-862101","title":"Biolegend, 862101, Purified anti-ApoER2 (LRP8) Antibody, 25μg","description":"\u003cp\u003eLDL Receptor Related Protein 8 (LRP8), also known as ApoER2, is a receptor for members of low-density lipoproteins. LRP8 interacts with its ligand reelin, and triggers reelin signaling to regulate cellular processes such as neuronal cell migration and long-term potentiation of mature neurons. LRP8 also interacts with and downregulates APP endocytosis. This interactions leads to increased amyloid beta production, demonstrating a major role for LRP8 in the pathogenesis of  Alzheimer’s disease.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2801239 (BioLegend Cat. No. 862101) AB_2801240 (BioLegend Cat. No. 862102)\u003cbr\u003e\nStructure: LRP8 is a 963 amino acid protein with an apparent molecular mass of ~105 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: brain, endocrine tissue, testis, and placenta Cellular Distribution: plasma membrane, extracellular, and cytoskeleton\u003cbr\u003e\nFunction: LRP8 functions as the receptor for reelin. Binding and endocytosis of reelin triggers downstream signaling pathways that affects neuronal migration and postnatal LTP.\u003cbr\u003e\nInteraction: FE65, JIP1, JIP2, Thrombosphondin, F-Spondin\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Neurodegeneration, Neuroscience, Protein Trafficking and Clearance\u003cbr\u003e\nMolecular Family: Apolipoproteins\u003cbr\u003e\nAntigen References: Santana J and Marzolo MP. 2017. Biochem J. 474(18):3137 Kim J, et al. 2014. Mol Cells. 37(11):767 Lara-Castillo N and Johnson ML. 2015. Rev Endocr Metab Disord. 16(2):141\u003cbr\u003e\nGene ID: 780416975\u003cbr\u003e\nUniProt: View information about ApoER2 on UniProt.org\u003cbr\u003e\nClone: 25G5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: LRP8, APOER2, LDL Receptor Related Protein 8\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860881035433,"sku":"862101","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-862101","provider":"Iright","version":"1.0","type":"link"}