{"product_id":"biolegend-862302","title":"Biolegend, 862302, Purified anti-Gemin 6 Antibody, 100μg","description":"\u003cp\u003eGem-associated protein 6 (Gemin 6) is a component of the survival of motor neurons (SMN) macromolecule protein complex, which plays an important role in the assembly and re-structuring of small nucleoproteins and transcriptosomes. The SMN complex localizes to the cytosol and nucleus of eukaryotic cells.  Gemin 6 has been shown to form heterodimers with Gemin 7, and together they bind to unrip and sequester the SMN complex in the cytoplasm for small nuclear ribonucleoproteins (snRNP) assembly 3 .\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone is more reactive to mouse compared to human or rat Gemin 6. The recommended usage concentration for Western blotting in mouse is 0.2 - 1 µg\/ml, and in human and rat 5.0 - 10 µg\/mL\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Massenet S, et al. 2002. Mol Cell Biol. 22(18):6533 (WB) Battle DJ, et al. 2007. J Biol Chem. 282(38):27953 (IP)\u003cbr\u003e\nProduct Citations: Bizen N, et al. 2022. Cell Death Differ. . PubMed\u003cbr\u003e\nRRID: AB_2810749 (BioLegend Cat. No. 862301) AB_2810750 (BioLegend Cat. No. 862302)\u003cbr\u003e\nStructure: Gemin 6 is a 167 amino acid protein with an apparent molecular mass of ~19 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Nucleus and cytosol\u003cbr\u003e\nFunction: Gemin 6 is a component of the SMN complex essential for the formation of snRNP complexes in Eukaryotic cells.\u003cbr\u003e\nInteraction: Gemin-7, unrip\u003cbr\u003e\nCell Type: Mature Neurons, Neurons\u003cbr\u003e\nBiology Area: Chromatin Remodeling\/Epigenetics, Neurodegeneration, Neuroscience\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: Lanfranco M, et al. 2017. FEBS Lett. 591(21):3600 Massenet S, et al. 2002. Mol Cell Biol. 22(18):6533 Battle DJ, et al. 2007. J Biol Chem. 282(38):27953\u003cbr\u003e\nGene ID: 79833\u003cbr\u003e\nUniProt: View information about Gemin 6 on UniProt.org\u003cbr\u003e\nClone: 6H5\/Gemin6\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Gemin6\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862480244905,"sku":"862302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-862302","provider":"Iright","version":"1.0","type":"link"}