{"product_id":"biolegend-862602","title":"Biolegend, 862602, Purified anti-β Catenin 1 Antibody, 100μg","description":"\u003cp\u003eβ catenin is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. β catenin also plays a key role in Wnt signaling pathways and thus is involved in neural differentiation, synaptic plasticity, neurodegenerative disease, and prevention of apoptosis. This protein also binds to adenomatous polyposis coli, which is mutated in the adenomatous polyposis of the colon.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P, ICFC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.5 - 10 µg\/mL is suggested. For intracellular flow cytometry using our True-Nuclear™ Transcription Factor Staining Protocol, the suggested use of this reagent is ≤ 0.06 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Guo J, et al. 2018. Cell Res. 28:1141 (IHC-P) Kisoh K, et al. 2017. Mol Neurobiol. 54:7917 (WB) Uribe RA, et al. 2015. J Cell Biol. 4:815 (IHC-F)\u003cbr\u003e\nProduct Citations: Ye L, et al. 2021. Drug Dev Res. 82:1162. PubMed\u003cbr\u003e\nRRID: AB_2801245 (BioLegend Cat. No. 862601) AB_2801246 (BioLegend Cat. No. 862602)\u003cbr\u003e\nStructure: β Catenin is a 781 amino acid protein with an apparent molecular mass of ~ 86 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Plasma membrane, cytoskeleton, nucleus, cytosol, and extracellular\u003cbr\u003e\nFunction: β Catenin is a dual functional protein involved in cell-cell adhesion and gene transcription.\u003cbr\u003e\nInteraction: E-cadherin\/CDH1, LEF1, TCF4, etc.\u003cbr\u003e\nAntigen References: Dias C, et al. 2014. Nature. 516(7529): 51 Rosiles A, et al. 2016. CNS Neurol Disord Drug Targets. 15(1):3 Na K, et al. 2017. Anticancer Res. 37(6):3249 Zhu P, et al. 2018. Cancer Res Treat. 50(4):1452\u003cbr\u003e\nGene ID: 14991238784353\u003cbr\u003e\nUniProt: View information about beta Catenin 1 on UniProt.org\u003cbr\u003e\nClone: 15B8\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: β-catenin, CTNNB1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860811960489,"sku":"862602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-862602","provider":"Iright","version":"1.0","type":"link"}