{"product_id":"biolegend-865501","title":"Biolegend, 865501, Purified anti-Gemin 3 Antibody, 25μg","description":"\u003cp\u003eGemin 3, also known as DEAD-box helicase 20 (DDX20), is a putative RNA helicase that contains a conserved ASP-GLU-ALA-ASP (DEAD) motif. Gemin 3 is involved in a variety of cellular processes including initiation of protein translation, ribosome assembly, and alteration of RNA secondary structure. Gemin 3 is one of the core components of the survival of motor neurons (SMN) macromolecule protein complex, which plays an important role in the assembly and re-structuring of small nucleoproteins and transcriptosomes. Gemin 3 may also be involved in cancer as it acts as a tumor suppressor in hepatocellular carcinoma, and as a tumor promoter in breast cancer and prostate cancer 2 .\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2810775 (BioLegend Cat. No. 865501) AB_2810776 (BioLegend Cat. No. 865502)\u003cbr\u003e\nStructure: Gemin 3 is an 824 amino acid protein with an apparent molecular mass of ~ 92 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Testis and ovary Cellular Distribution: Cytosol, nucleus, and cytoskeleton\u003cbr\u003e\nFunction: Gemin 3 is a component of SMN macromolecule protein complex.\u003cbr\u003e\nInteraction: SMN, GEMIN4\u003cbr\u003e\nCell Type: Astrocytes, GABAergic Neurons, Glutamatergic Neurons, Mature Neurons, Microglia, Neural Stem Cells, Neurons, Oligodendrocytes\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Neurodegeneration, Neuroscience, Synaptic Biology, Transcription Factors\u003cbr\u003e\nAntigen References: Seng CO, et al. 2015. Hum. Mol. Genet. 24(8):2138. Chen W, et al. 2016. Int. J. Mol. Med. 37(6):1551.\u003cbr\u003e\nGene ID: 11218\u003cbr\u003e\nUniProt: View information about Gemin 3 on UniProt.org\u003cbr\u003e\nClone: 12H12\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Gemin3\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860798820521,"sku":"865501","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-865501","provider":"Iright","version":"1.0","type":"link"}