{"product_id":"biolegend-866302","title":"Biolegend, 866302, Purified anti-Galectin-7 Antibody, 100μg","description":"\u003cp\u003eThe galectins are a family of beta-galactoside-binding proteins implicated in cell-cell and cell-matrix interactions. Galectin-7 is specifically expressed in stratified epithelia and epidermis, but barely detected in epidermal tumors and absent from squamous carcinoma cell lines. Galectin-7 is a p53-induced protein and is abnormally expressed in variety of tumors such as melanoma, lung cancer and colon cancer. In UVB-induced sunburn keratinocytes, the expression of Galectin-7 is markedly increased due to the genotoxic stress-induced p53 activation. Both positive and negative regulatory roles of Galectin-7 have been reported in tumorigenesis.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant human Galectin-7\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 1.0 - 10 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2820164 (BioLegend Cat. No. 866301) AB_2820165 (BioLegend Cat. No. 866302)\u003cbr\u003e\nStructure: Human Galectin-7 is a 136 amino acid protein with a molecular mass of 15 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Stratified squamous epithelium Cellular distribution: Nucleus, extracellular region or secreted, and cytoplasm\u003cbr\u003e\nFunction: Galectin-7 is involved in the cell-cell and cell-matrix interactions.\u003cbr\u003e\nLigand\/Receptor: Carbohydrates\u003cbr\u003e\nCell Type: Epithelial cells\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Cell Adhesion, Cell Biology, Neurodegeneration\u003cbr\u003e\nMolecular Family: Adhesion Molecules, Soluble Receptors\u003cbr\u003e\nAntigen References: Bernerd F. et al. 1999. Proc Natl Acad Sci U S A. 96(20):11329-34. Madsen P. et al. 1995. J Biol Chem. 270(11):5823-9. Biron-Pain K. et al. 2013. PLoS One. 8(5):e63307.\u003cbr\u003e\nGene ID: 3963\u003cbr\u003e\nUniProt: View information about Galectin-7 on UniProt.org\u003cbr\u003e\nClone: A18059A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Galectin 7, Gal-7, GAL7, HKL-14, PI7, PIG1, p53-induced gene 1 protein, TP53I1, LGALS7A\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866060378281,"sku":"866302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-866302","provider":"Iright","version":"1.0","type":"link"}