{"product_id":"biolegend-866902","title":"Biolegend, 866902, Purified anti-PLAP Antibody, 100μg","description":"\u003cp\u003ePLAP is a membrane-bound glycosylated dimeric enzyme that was initially identified in the placenta. PLAP is also known as phospholipase A2 activating protein. Abnormal amyloid beta-induced activation of synaptic phospholipase A2 results in synaptic degeneration due to elevated levels of platelet-activating factor, suggesting that PLAP may be a contributing factor in synaptic damage observed in Alzheimer’s disease patients. Clinically, PLAP is broadly used as a tumor marker, especially in geminoma, seminoma, and ovarian cancer.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality testedWB - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 2.0 - 10 µg\/ml is suggested. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2810793 (BioLegend Cat. No. 866901) AB_2810794 (BioLegend Cat. No. 866902)\u003cbr\u003e\nStructure: PLAP is a 795 amino acid protein with predicted molecular mass of ~87 kD and observed molecular mass of ~70 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Plasma membrane\u003cbr\u003e\nFunction: Phospholipase A2 activating protein that may be involved in amyloid beta-induced synaptic degeneration.\u003cbr\u003e\nInteraction: Ubiquitin, UBXN6, VCP, YOD1\u003cbr\u003e\nCell Type: Astrocytes, Endothelial cells, Neurons\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Neurodegeneration, Neuroscience, Synaptic Biology\u003cbr\u003e\nMolecular Family: Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: Watanabe S et al., 2012. Pediatr Neurosurg. 48(3):141 Bate C et al., 2010. Mol Neurodegener. 5:13 Huynh ML et al., 2011. Genesis. 49(11):851\u003cbr\u003e\nGene ID: 18786\u003cbr\u003e\nUniProt: View information about PLAP on UniProt.org\u003cbr\u003e\nClone: 8A11-C11-C9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: ALPP, PLAA, , Placental Alkaline Phosphatase 1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862492598441,"sku":"866902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-866902","provider":"Iright","version":"1.0","type":"link"}