{"product_id":"biolegend-867001","title":"Biolegend, 867001, Purified anti-FXR1 Antibody, 25μg","description":"\u003cp\u003eFXR1 is an RNA binding protein that interacts with polyribosomes, specifically with the 60S ribosome subunit. In the adult brain, FXR1 is mainly localized to the cytoplasm and the proximal dendrites of neurons. In the fetal brain, FXR1 is expressed in the nucleus of neurons. Clinically, FXR1 mutations have been identified as a major genetic contributing factor to fragile X mental retardation syndrome. Recent studies also suggest that FXR family of proteins integrate dopamine signaling and glutamatergic neurotransmission.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human FXR1\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - VerifiedICC - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 - 10 µg per ml. For immunohistochemistry, a concentration range of 1 - 5 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Xu XL, et al. 2011. J. Neurosci. 31(39):13705-9. (WB) Battle DJ, et al. 2007. J. Biol. Chem. 282(38):27953-9. (ICC)\u003cbr\u003e\nRRID: AB_2810795 (BioLegend Cat. No. 867001) AB_2810796 (BioLegend Cat. No. 867002)\u003cbr\u003e\nStructure: FXR1 is a 621 amino acid protein with predicted molecular mass of ~ 70 kD and observed molecular mass of ~ 75kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Cytosol and nucleus\u003cbr\u003e\nFunction: FXR1 is an RNA binding protein involved in neurodevelopmental diseases such as autism, schizophrenia, and fragile X mental retardation.\u003cbr\u003e\nInteraction: Polyribosome, FXR2, FMR1, CYFIP2\u003cbr\u003e\nCell Type: Dopaminergic Neurons, GABAergic Neurons, Neurons, Oligodendrocytes\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroscience, Signal Transduction, Synaptic Biology, Transcription Factors\u003cbr\u003e\nMolecular Family: Postsynaptic proteins, Presynaptic proteins\u003cbr\u003e\nAntigen References: Khlghatyan J, Beaulieu JM. 2018. Front Synaptic. Neurosci. 10:22. Bardoni B, et al. 2001. Brain Res. Bull. 56:375-82. Inoue SB, et al. 2000. J. Med. Invest. 47(3-4):101.\u003cbr\u003e\nGene ID: 8087\u003cbr\u003e\nUniProt: View information about FXR1 on UniProt.org\u003cbr\u003e\nClone: 6BG10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: FMR1 Autosomal Homolog 1, Fragile X Mental Retardation Syndrome-Related Protein 1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862473887913,"sku":"867001","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-867001","provider":"Iright","version":"1.0","type":"link"}