{"product_id":"biolegend-870802","title":"Biolegend, 870802, Purified anti-GlyT2 (SLC6A5) Antibody, 100μg","description":"\u003cp\u003eGlycine transporter 2 (GlyT2) protein is encoded by the SLC6A5 gene. It is one of the major glycine transporters that is expressed predominantly in the brain stem and spinal cord, and is frequently used as cellular marker for glycinergic neurons in the central nervous system. Mutations in the SLC6A5 gene have been clinically linked to hyperekplexia 3, which has been thought to be caused by disruption of inhibitory neuronal transmission.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Synthetic peptide corresponding to a.a. 182-199 of mouse SLC6A5\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 1 - 5 µg\/mL. For immunocytochemistry, a concentration range of 2 - 10 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2820198 (BioLegend Cat. No. 870801) AB_2820199 (BioLegend Cat. No. 870802)\u003cbr\u003e\nStructure: GlyT2 is a 797 amino acid protein with predicted and observed molecular mass of ~87 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Brain Cellular Distribution: Plasma Membrane\u003cbr\u003e\nFunction: Glycine transport and recycling\u003cbr\u003e\nLigand\/Receptor: Glycine\u003cbr\u003e\nCell Type: Mature Neurons, Neurons\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: Neurotransmitter Receptor Trafficking\/Endocytosis, Presynaptic proteins\u003cbr\u003e\nAntigen References: Zafra F, et al. 2017. Adv Neurobiol. 16:55. Lopez-Corcuera B, et al. 2017. Adv Neurobiol. 16:13. Vandenberg RJ, et al. 2014. Trends Pharmacol Sci. 35(8):423.\u003cbr\u003e\nGene ID: 9152171148\u003cbr\u003e\nUniProt: View information about GlyT2 on UniProt.org\u003cbr\u003e\nClone: A18174E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: GLYT-2, NET1, HKPX3, Glycine Transporter 2\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866063032489,"sku":"870802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-870802","provider":"Iright","version":"1.0","type":"link"}