{"product_id":"biolegend-871002","title":"Biolegend, 871002, Purified anti-BRAP Antibody, 100μg","description":"\u003cp\u003eBRCA1 associated protein (BRAP) is a cytosolic protein that negatively regulates MAP kinase activation by inhibiting the formation of the Raf\/MEK complex. BRAP also inhibits nuclear translocation and promotes the retention of several proteins, including BRCA1, in the cytoplasm by binding to their nuclear localization signal sequence.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified recombinant human BRAP protein fragments expressed in E. coli\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 2.0 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 2.0 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2832876 (BioLegend Cat. No. 871001) AB_2832877 (BioLegend Cat. No. 871002)\u003cbr\u003e\nStructure: BRAP is an 592 amino acid protein with predicted and observed molecular mass of ~67 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Nucleus, Cytosol\u003cbr\u003e\nFunction: Protein trafficking, Epigenetics\u003cbr\u003e\nInteraction: BRCA1, Galectin-2\u003cbr\u003e\nCell Type: Astrocytes, Dopaminergic Neurons, GABAergic Neurons, Glutamatergic Neurons, Mature Neurons, Microglia, Neural Stem Cells, Neurons, Oligodendrocytes\u003cbr\u003e\nBiology Area: Cell Biology, Innate Immunity, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Trafficking and Clearance, Ubiquitin\/Protein Degradation\u003cbr\u003e\nMolecular Family: Innate Immune Signaling\u003cbr\u003e\nAntigen References: Modell SM, et al. 2014. J Relig Health. 53(3):715. Castro E \u0026amp; Eeles R. 2012. Asian J Androl. 14(3):409. Pristauz G, et al. 2010. Wien Med Wochenschr. 160(7-8):158.\u003cbr\u003e\nGene ID: 831572399\u003cbr\u003e\nUniProt: View information about BRAP on UniProt.org\u003cbr\u003e\nClone: 1E7-C9-D10-B10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: BRCA1 Associated Protein\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860857311401,"sku":"871002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-871002","provider":"Iright","version":"1.0","type":"link"}