{"product_id":"biolegend-871401","title":"Biolegend, 871401, Purified anti-Calretinin Antibody, 25μg","description":"\u003cp\u003eCalretinin is a calcium-binding protein that is abundantly expressed in interneurons and multiple regions of the brain, including the brainstem, hypothalamus, hippocampus, and cerebellum. Calretinin is involved in regulating intracellular calcium signaling and modulating neuronal excitability. Loss and reorganization of calretinin-positive interneurons have been indicated as possible cause in human epilepsy. In addition, calretinin is considered as the most sensitive and specific marker for the diagnosis of malignant mesothelioma.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human CALB2\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.1 - 2.0 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2861109 (BioLegend Cat. No. 871401) AB_2861110 (BioLegend Cat. No. 871402)\u003cbr\u003e\nStructure: Human calretinin is a 271 amino acid protein with a predicted molecular mass of 31 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Brain Cellular distribution: Cytosol, cytoskeleton, nucleus, plasma membrane\u003cbr\u003e\nFunction: Calretinin regulates intracellular calcium signaling and modulates neuronal excitability.\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Cell Biology, Neuroinflammation, Neuroscience, Synaptic Biology\u003cbr\u003e\nAntigen References: Wörthmüller J, et al. 2018. Oncotarget. 9(91):36256-36272. Christel CJ, et al. 2012. J Biol Chem. 287(47):39766-75. Tóth K, et al. 2010. Brain. 133(9):2763-77.\u003cbr\u003e\nGene ID: 794\u003cbr\u003e\nUniProt: View information about Calretinin on UniProt.org\u003cbr\u003e\nClone: A18241B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CR, 29 KDa calbindin, CAB29, CALB2, Calbindin 2, Calbindin D29K, CAL2\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866064507049,"sku":"871401","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-871401","provider":"Iright","version":"1.0","type":"link"}