{"product_id":"biolegend-906801","title":"Biolegend, 906801, Purified anti-HIV gp120 Antibody (Previously Covance catalog# MMS-193P), 250microl","description":"\u003cp\u003eGlycoprotein 120, or gp120, is a human immunodeficiency virus (HIV) envelope protein derived from the proteolytic cleavage of gp160. It attaches HIV to host lymphoid cells by binding to the primary receptor CD4. This binding interaction induces a structural rearrangement creating another high affinity binding site for a chemokine co-receptor like CXCR4 and\/or CCR5. The protein also serves as a ligand for CD209\/DC-SIGN and CLEC4M\/DC-SIGNR. CD209 in particular is an important interaction as dendritic cells loaded with viral particles can migrate to lymph nodes to provide access to T cells for infection.\u003cbr\u003e\n250microl\u003cbr\u003e\nVerified Reactivity: HIV\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: This antibody was raised against a peptide corresponding to the amino acid sequence 427-448 of the gp120 protein.\u003cbr\u003e\nFormulation: Phosphate-buffered solution + 0.03% Thimerosal.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 1 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.\u003cbr\u003e\nApplication: WB\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. The optimal working dilution should be determined for each specific assay condition. • WB: 1:500*\u003cbr\u003e\nApplication Notes: This antibody is effective in immunoblotting. *Predicted MW = 120 kD\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Not Published\u003cbr\u003e\nRRID: AB_2565069 (BioLegend Cat. No. 906801)\u003cbr\u003e\nBiology Area: Bacterial proteins and Toxins, Cell Biology, Signal Transduction\u003cbr\u003e\nGene ID: 155971\u003cbr\u003e\nUniProt: View information about HIV gp120 on UniProt.org\u003cbr\u003e\nClone: ED8.D4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: HTLV-III gp120, Envelope Glycoprotein gp120, HIV, gp120(HIV), HIV Envelope Glycoprotein gp120, HTLV III gp120, env Protein gp120, HIV, gp120 Envelope Glycoprotein, HIV, gp120, HTLV-III\u003cbr\u003e\nPreviously: Covance Catalog# MMS-193P\u003cbr\u003e\nIsotype: Mouse IgG1\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46863069282473,"sku":"906801","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-906801","provider":"Iright","version":"1.0","type":"link"}