{"product_id":"biolegend-915004","title":"Biolegend, 915004, Purified anti-BRST-1 Antibody, 100μg","description":"\u003cp\u003eBRST1 is a carcinoma-associated antigen and a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: This antibody was generated against a protein secreted by the T47D (clone 11) human breast carcinoma cell line.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 5.0 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: CU-18 detects a human breast carcinoma associated glycoprotein BCA-225, a 225 kD glycoprotein secreted by the T47D breast carcinoma cell line.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Imam SA, et al. 1995. Anticancer Res. 15:1153. PubMed Ansai S, et al. 1994. J. Dermatol. 21(1):20. PubMed Ma CK, et al. 1993. Am. J. Clin. Pathol. 99(5):551. PubMed\u003cbr\u003e\nRRID: AB_2616963 (BioLegend Cat. No. 915004)\u003cbr\u003e\nStructure: BRST-1 is a 35 kD protein.\u003cbr\u003e\nDistribution: Cytoplasm, extracellular, and nucleus.\u003cbr\u003e\nFunction: BRST-1 may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. BRST-1 plays a role in embryonic stem cells proliferation and differentiation.\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology\u003cbr\u003e\nGene ID: 4072\u003cbr\u003e\nUniProt: View information about BRST-1 on UniProt.org\u003cbr\u003e\nClone: CU-18\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: EPCAM, Epithelial cell adhesion molecule, epithelial glycoprotein 314, Tumor-Associated Calcium Signal Transducer 1, Adenocarcinoma-Associated Antigen, Cell Surface Glycoprotein Trop-1, CD326 Antigen\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866086985897,"sku":"915004","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-915004","provider":"Iright","version":"1.0","type":"link"}