{"product_id":"biolegend-948202","title":"Biolegend, 948202, Purified anti-SHP-2 Antibody, 100μg","description":"\u003cp\u003eSrc homology-2-containing protein tyrosine phosphatase 2 (SHP-2) protein, encoded by PTPN11 gene, is a well-known oncogenic protein tyrosine phosphatase. SHP-2 regulates cellular functions by dephosphorylating targets downstream of PD1, EGFRvIII, HGF receptor, and cytokine receptors. Cellular processes controlled by SHP-2 include mitotic cycle, cell growth, differentiation, and oncogenesis. SHP-2 has been recognized as a potential therapeutic target for cancers including breast cancer, lung cancer, leukemia, gastric cancer, and oral cancer.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Synthetic peptide from human SHP-2\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 1.0 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This antibody recognizes endogenous human and mouse SHP-2 proteins in K-562, HeLa, HEK293, and NIH\/3T3 cell lysates by WB.\u003cbr\u003e\nProduct Citations: Taylor J, et al. 2023. Front Immunol. 14:1119350. PubMed\u003cbr\u003e\nRRID: AB_2894536 (BioLegend Cat. No. 948201) AB_2894536 (BioLegend Cat. No. 948202)\u003cbr\u003e\nStructure: SHP-2 is a 593 amino acid protein with a molecular mass of 68 kD.\u003cbr\u003e\nDistribution: Cytoplasm and Nucleus\u003cbr\u003e\nFunction: SHP-2 regulates cell proliferation, apoptosis, invasion, and metastasis.\u003cbr\u003e\nInteraction: SHP-2 interacts with PD1, EGFR, HGF receptor, RET, FGFR2, FGFR3, PI3K\/AKT, and TLR3 signaling pathways.\u003cbr\u003e\nCell Type: Lymphocytes, T cells, Th1\u003cbr\u003e\nBiology Area: Cell Biology, Cell Proliferation and Viability, Immuno-Oncology, Immunology\u003cbr\u003e\nMolecular Family: Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: Hao C, et al. 2020. Oncogene. 39:7166-7180. Marie D., et al. 2008. Cell Signal. 20:453-9. Cheng Kui QU. 2000. Cell Research. 10:279-288.\u003cbr\u003e\nGene ID: 5781\u003cbr\u003e\nUniProt: View information about SHP-2 on UniProt.org\u003cbr\u003e\nClone: A20016A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CFC, NS1, JMML, SHP2, BPTP3, PTP2C, METCDS, PTP-1D, SH-PTP2, SH-PTP3, Syp, Protein Tyrosine Phosphatase Non-Receptor Type 11, SH2 Domain-Containing Protein Tyrosine Phosphatase 2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866068701353,"sku":"948202","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-948202","provider":"Iright","version":"1.0","type":"link"}