{"product_id":"cst-30068t","title":"CST,  30068T, Cystathionine gamma-Lyase (D4E9J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CTH. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Cystathionine gamma-Lyase (D4E9J) Rabbit Monoclonal Antibody (CST #30068) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCystathionine gamma-Lyase (D4E9J) Rabbit Monoclonal Antibody recognizes endogenous levels of total cystathionine γ-lyase protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human cystathionine γ-lyase protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCystathionine γ-lyase (CGL) is an enzyme in the transsulfuration pathway, a route in the metabolism of sulfur-containing amino acids (1). This enzyme regulates local vasodilation and blood pressure by generating hydrogen sulfide (H S) as a physiological signaling molecule (2). A rodent model of sleep apnea showed that H S production by cystathionine γ-lyase in the carotid body triggers hypertension in rodents during intermittent hypoxia, suggesting that inhibition of this enzyme may prevent the hypertension associated with sleep apnea (3). In addition, dietary restriction of sulfur-containing amino acids upregulates hepatic cystathionine γ-lyase expression in mice, leading to elevated production of H S and protection from hepatic ischemia perfusion injury, indicating that this enzyme is critical for the benefits of dietary restriction (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCGL; CTH; cystathionase (cystathionine gamma-lyase); Cystathionine gamma-lyase; cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; homoserine deaminase; homoserine dehydratase; MGC9471\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 44\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798064418985,"sku":"30068T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/cst-30068t","provider":"Iright","version":"1.0","type":"link"}