{"product_id":"cst-33293s","title":"CST,  33293S, CD11c (N418) Hamster Monoclonal Antibody (APC Conjugate)","description":"Monoclonal Antibody for studying ITGAX mouse. Validated for Flow Cytometry (Live). Highly specific and rigorously validated in-house, CD11c (N418) Hamster Monoclonal Antibody (APC Conjugate) (CST #33293) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFor optimal flow cytometry results, we recommend 0.125 μg of antibody per test.\nFlow Cytometry (Live): 1:160\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2. This product is stable for 12 months when stored at 4ºC. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Flow Cytometry (Live)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD11c (N418) Hamster Monoclonal Antibody (APC Conjugate) recognizes endogenous levels of total CD11c protein. This antibody conjugate detects an epitope within the extracellular domain.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nThis monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.\n\u003cb\u003eBackground\u003c\/b\u003e\nCD11c (integrin αX, ITGAX) is a transmembrane glycoprotein that forms an α\/β heterodimer with CD18 (integrin β2), which interacts with a variety of extracellular matrix molecules and cell surface proteins (1). CD11c is primarily used as a dendritic cell marker. Dendritic cells can be classified into two major types: CD11c+ conventional dendritic cells that specialize in antigen presentation, and CD11c- plasmacytoid dendritic cells that specialize in type I interferon production (2, 3). CD11c expression has also been observed on activated NK cells, subsets of B cells, monocytes, granulocytes, and some B cell malignancies including hairy cell leukemia (4-7). The N418 antibody is widely used as a marker for CD11c expression on the cell types mentioned above (8,9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAI449405; CD11 antigen-like family member C; Cd11c; CD11C (p150) alpha polypeptide; complement receptor 4; Cr4; integrin alpha X; Integrin alpha-X; integrin aX; ITAX; Itgax; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95; mFLJ00114; MFLJ00114 protein; N418\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nSource\/Isotype: Hamster (armenian) IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800379740329,"sku":"33293S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/cst-33293s","provider":"Iright","version":"1.0","type":"link"}