{"product_id":"cst-3408s","title":"CST,  3408S, VEGF Receptor 3 (C82A2) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying VEGFR3. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, VEGF Receptor 3 (C82A2) Rabbit Monoclonal Antibody (CST #3408) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nVEGF Receptor 3 (C82A2) Rabbit Monoclonal Antibody detects transfected levels of VEGF receptor 3 protein. This antibody does not cross-react with other family members.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr1363 of human VEGF receptor 3.\n\u003cb\u003eBackground\u003c\/b\u003e\nVascular endothelial growth factor receptor 3 (VEGFR3) is a 195 kDa membrane receptor tyrosine kinase. VEGF receptors are characterized by the presence of seven extracellular immunoglobulin (Ig)-like domains followed by a membrane-spanning domain and a conserved intracellular tyrosine kinase domain (1). VEGF receptor 3 expression is largely restricted to adult lymphatic endothelium and is thought to control lymphangiogenesis (1,2). Binding of VEGF-C\/VEGF-D to VEGFR3 results in transphosphorylation of tyrosine residues in its intracellular domain, recruitment of signaling molecules and activation of ERK1\/2 and Akt signaling cascades (1,3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCHTD7; Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4; FLT-4; FLT4; FLT41; fms related receptor tyrosine kinase 4; fms related tyrosine kinase 4; Fms-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; LMPHM1; PCL; primary congenital lymphedema; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; Tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; VEGF receptor-3; VEGFR-3; VEGFR3; VGFR3\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Transfected Only\nMW (kDa): 195\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799415804073,"sku":"3408S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/cst-3408s","provider":"Iright","version":"1.0","type":"link"}