{"product_id":"cst-4394s","title":"CST,  4394S, beta-TrCP (D13F10) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying beta-Trcp. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, beta-TrCP (D13F10) Rabbit Monoclonal Antibody (CST #4394) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nbeta-TrCP (D13F10) Rabbit Monoclonal Antibody detects endogenous levels of total β-TrCP protein. This antibody also recognizes a 40 kDa band of unknown origin.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile69 of human β-TrCP protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nβ-transducin repeat-containing protein (β-TrCP or FBW1A) is an F-box family protein characterized by the presence of the protein-protein mediating F-box domain first described in cyclin F. F-box proteins act as substrate adaptors that target proteins containing a specific phosphorylated sequence element, referred to as a phosphodegron, to the SCF E3 ubiquitin ligase complex for ubiquitination (1,2). β-TrCP targets many important proteins with diverse functions, such as p53, H-Ras, Smad4, IκBα, β-catenin, and the cell cycle checkpoint protein claspin, for ubiquitin-mediated degradation (3-5). Research studies have shown that inhibition of β-TrCP expression has a demonstrated benefit in the treatment of prostate cancer (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nbeta-transducin repeat containing; beta-transducin repeat containing E3 ubiquitin protein ligase; BETA-TRCP; beta-TrCP1; betaTrCP; BTRC; BTRCP; bTrCP1; E3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; F-box and WD-repeat protein 1B; F-box\/WD repeat-containing protein 1A; FBW1A; FBXW1; FBXW1A; FWD1; MGC4643; pIkappaBalpha-E3 receptor subunit\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 62\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799509094569,"sku":"4394S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/cst-4394s","provider":"Iright","version":"1.0","type":"link"}