{"product_id":"proteintech-11112-1-ap","title":"Proteintech, 11112-1-AP, ARHGEF10 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe ARHGEF10 (11112-1-AP) by Proteintech is a Polyclonal antibody targeting ARHGEF10 in IHC, ELISA applications with reactivity to human, mouse, rat samples\n11112-1-AP targets ARHGEF10 in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive IHC detected in: human lung cancer tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nImmunohistochemistry (IHC): IHC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nARHGEF10(Rho guanine nucleotide exchange factor 10), also named as KIAA0294, is a member of the family of Rho guanine nucleotide exchange factors (GEFs), which are implicated in neural morphogenesis and connectivity and regulate the activity of small Rho GTPases by catalyzing the exchange of bound GDP by GTP(PMID:14508709). The deduced 1,121-amino acid protein shares significant similarity with cell signaling proteins(PMID:9205841). Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV)(PMID:14508709). It has 5 isoforms produced by alternative splicing.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nCited Reactivity: mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag1605 Product name: Recombinant human ARHGEF10 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 342-641 aa of BC036809 Sequence: YLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRAADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEENHMGWFCVEDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWVRCVY Predict reactive species\nFull Name: Rho guanine nucleotide exchange factor (GEF) 10\nCalculated Molecular Weight: 147 kDa\nGenBank Accession Number: BC036809\nGene Symbol: ARHGEF10\nGene ID (NCBI): 9639\nRRID: AB_2059754\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: O15013\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869515927721,"sku":"11112-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-11112-1-ap","provider":"Iright","version":"1.0","type":"link"}