{"product_id":"proteintech-14850-1-ap","title":"Proteintech, 14850-1-AP, Phospho-GSK3B (Ser389) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-GSK3B (Ser389) (14850-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-GSK3B (Ser389) in WB, ELISA applications with reactivity to mouse, rat samples\n14850-1-AP targets Phospho-GSK3B (Ser389) in WB, IF, ELISA applications and shows reactivity with mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Calyculin A treated NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nGlycogen synthase kinase 3s are serine\/threonine kinases that were originally identified as key regulatory enzymes in glucose metabolism. There are two isoforms, GSK3α and GSK3β, encoded by separate genes, which are overall 85% homologous to each other, with 95% identity in the kinase domains. To date, phosphorylation at Ser9 by Akt is the best-characterized mechanism for the inhibition of GSK3β activity. GSK3β is phosphorylated at S389 in vivo by p38 MAPK and that this alternative regulatory mechanism of GSK3β is tissue-specific(PMID:18451303).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: mouse, rat\nCited Reactivity: human, mouse, rat, pig\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: glycogen synthase kinase 3 beta\nCalculated Molecular Weight: 48 kDa\nObserved Molecular Weight: 46-50 kDa\nGenBank Accession Number: BC060743\nGene Symbol: Gsk3b\nGene ID (NCBI): 56637\nRRID: AB_2878085\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q9WV60\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46868841791657,"sku":"14850-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-14850-1-ap","provider":"Iright","version":"1.0","type":"link"}