{"product_id":"proteintech-16930-1-ap","title":"Proteintech, 16930-1-AP, TBX2 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe TBX2 (16930-1-AP) by Proteintech is a Polyclonal antibody targeting TBX2 in WB, IHC, IF\/ICC, ELISA applications with reactivity to human samples\n16930-1-AP targets TBX2 in WB, IHC, IF\/ICC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: A549 cells, BxPC-3 cells,  human placenta tissue,  SW 1990 cells,  human kidney tissue,  rat kidney tissue\nPositive IHC detected in: human kidney tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\nPositive IF\/ICC detected in: HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:3000\nImmunohistochemistry (IHC): IHC : 1:20-1:200\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nTBX2 is a member of the T-box transcription factor gene family, and is expressed in a variety of tissues and organs during embryogenesis. Loss of Tbx2 function is therefore not sufficient to upregulate expression of p19ARF, p16INK4a, p15INK4b or p21 in 9.5-10.5 dpc mouse embryos, nor can the Tbx2tm1Pa\/Tbx2tm1Pa phenotype be attributed to an excess of p53 (PMID: 35508658, 15459098). TBX2 is overexpressed in several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver, and bladder cancers and can suppress senescence, a cellular process, which serves as a barrier to cancer development (PMID: 15781639).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nCited Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag10393 Product name: Recombinant human TBX2 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-349 aa of BC052566 Sequence: MAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALAKPLPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPPAREPPTSPGAAPSPLRLHRARAEEKSCAAD Predict reactive species\nFull Name: T-box 2\nCalculated Molecular Weight: 702 aa, 74 kDa\nObserved Molecular Weight: 74 kDa\nGenBank Accession Number: BC052566\nGene Symbol: TBX2\nGene ID (NCBI): 6909\nRRID: AB_2200526\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q13207\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869611872425,"sku":"16930-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-16930-1-ap","provider":"Iright","version":"1.0","type":"link"}