{"product_id":"proteintech-17001-1-ap","title":"Proteintech, 17001-1-AP, METTL7B Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe METTL7B (17001-1-AP) by Proteintech is a Polyclonal antibody targeting METTL7B in WB, IHC, ELISA applications with reactivity to human, mouse, rat samples\n17001-1-AP targets METTL7B in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: mouse liver tissue, rat liver tissue\nPositive IHC detected in: mouse liver tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\nImmunohistochemistry (IHC): IHC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nMETTL7B is a membrane-associated small-molecule methyltransferase that catalyzes S-methylation of alkyl thiols, thereby linking thiol\/sulfur metabolism, redox homeostasis, and cellular stress responses. By influencing antioxidant enzyme expression and detoxification pathways, METTL7B plays a pivotal role in tumor growth and drug resistance, particularly in lung adenocarcinoma. Its upregulation in multiple cancers and involvement in redox\/thiol metabolism make it an emerging therapeutic target in oncology and possibly in metabolic\/oxidative stress-related disease settings. (PMID: 40068772)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nCited Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag10694 Product name: Recombinant human METTL7B protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 39-244 aa of BC020509 Sequence: MAVLTPKSNRKMESKKRELFSQIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPHFEKFLTKSMAENRHLQYERFVVAPGEDMRQLADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQVFEPTWKHIGDGCCLTRETWKDLENAQFSEIQMERQPPPLKWLPVGPHIMGKAVK Predict reactive species\nFull Name: methyltransferase like 7B\nCalculated Molecular Weight: 244aa,28 kDa\nObserved Molecular Weight: 28 kDa\nGenBank Accession Number: BC020509\nGene Symbol: METTL7B\nGene ID (NCBI): 196410\nRRID: AB_2142199\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q6UX53\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46868942782633,"sku":"17001-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-17001-1-ap","provider":"Iright","version":"1.0","type":"link"}