{"product_id":"proteintech-20166-1-ap","title":"Proteintech, 20166-1-AP, KATNAL1 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe KATNAL1 (20166-1-AP) by Proteintech is a Polyclonal antibody targeting KATNAL1 in WB, IP, ELISA applications with reactivity to human samples\n20166-1-AP targets KATNAL1 in WB, IP, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HEK-293 cells, Jurkat cells,  HeLa cells\nPositive IP detected in: HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\nImmunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate\n\u003cb\u003eBackground Information\u003c\/b\u003e\nKATNAL1 belongs to a family of microtubule-severing proteins and contains an N-terminal microtubule interaction and trafficking (MIT) domain, an ATPase AAA-type core domain, and a C-terminal Vps4_C domain. KATNAL1 is involved in regulating microtubule dynamics, which is essential for spermiogenesis and male fertility. It severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays(PMID: 22654668). In neurons, KATNAL1 plays a role in microtubule rearrangement during neuronal migration and process elongation. Additionally, mutations in KATNAL1 have been associated with intellectual disability and microcephaly in humans(PMID: 30448058).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag13960 Product name: Recombinant human KATNAL1 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-261 aa of BC000612 Sequence: MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELLEEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREVRPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAV Predict reactive species\nFull Name: katanin p60 subunit A-like 1\nCalculated Molecular Weight: 490 aa, 55 kDa\nObserved Molecular Weight: 50-55 kDa\nGenBank Accession Number: BC000612\nGene Symbol: KATNAL1\nGene ID (NCBI): 84056\nRRID: AB_2878651\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q9BW62\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887690043561,"sku":"20166-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-20166-1-ap","provider":"Iright","version":"1.0","type":"link"}