{"product_id":"proteintech-27575-1-ap","title":"Proteintech, 27575-1-AP, SLC6A19 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe SLC6A19 (27575-1-AP) by Proteintech is a Polyclonal antibody targeting SLC6A19 in WB, IHC, ELISA applications with reactivity to human, mouse samples\n27575-1-AP targets SLC6A19 in WB, IHC, ELISA applications and shows reactivity with human, mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Caco-2 cells, mouse kidney tissue,  PC-3 cells,  mouse small intestine tissue\nPositive IHC detected in: human small intestine tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:1000\nImmunohistochemistry (IHC): IHC : 1:200-1:800\n\u003cb\u003eBackground Information\u003c\/b\u003e\nSLC6A19, also named as B0AT1, encodes system B(0) transmembrane protein that mediates epithelial resorption of neutral amino acids across the apical membrane in kidney and intestine (PubMed: 15044460). The protein contains 634 amino acids and has 12 predicted transmembrane regions with highly expression in human kidney and small intestine and minimal in pancreas (PubMed: 15286787). The expression of SLC6A19 in intestinal cells depends on angiotensin converting enzyme 2 which is the cellular receptor for SARS-CoV-2 (PubMed: 32132184). Mutations in SLC6A19 cause Hartnup disease (PMID: 15286787, PMID: 15286788).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag24362 Product name: Recombinant human SLC6A19 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 295-403 aa of BC148801 Sequence: VHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVF Predict reactive species\nFull Name: solute carrier family 6 (neutral amino acid transporter), member 19\nCalculated Molecular Weight: 634 aa, 71 kDa\nObserved Molecular Weight: 71 kDa\nGenBank Accession Number: BC148801\nGene Symbol: SLC6A19\nGene ID (NCBI): 340024\nRRID: AB_3085970\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q695T7\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887807680681,"sku":"27575-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-27575-1-ap","provider":"Iright","version":"1.0","type":"link"}