{"product_id":"proteintech-28416-1-ap","title":"Proteintech, 28416-1-AP, CDKN2A\/P16-INK4A Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe CDKN2A\/P16-INK4A (28416-1-AP) by Proteintech is a Polyclonal antibody targeting CDKN2A\/P16-INK4A in WB, ELISA applications with reactivity to mouse, rat samples\n28416-1-AP targets CDKN2A\/P16-INK4A in WB, ELISA applications and shows reactivity with mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: NIH\/3T3 cells, Neuro-2a cells,  RAW 264.7 cells,  C6 cells,  mouse uterus tissue\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:2000\n\u003cb\u003eBackground Information\u003c\/b\u003e\np16INK4a is a pivotal protein encoded by the CDKN2A gene on human chromosome 9p21.  It functions as a tumor suppressor and is one of the most important regulators of the cell cycle. It acts as a cyclin-dependent kinase (CDK) inhibitor, specifically binding to CDK4 and CDK6 and blocking their association with cyclin D. Beyond cell-cycle control, p16INK4a is a key mediator of cellular senescence-an irreversible growth-arrest state that limits the expansion of damaged or oncogene-expressing cells. Its expression rises with age and in response to stresses such as DNA damage or oncogenic signaling, making it a biomarker of both biological aging and tumorigenic stress. In human cancers, the p16INK4a-RB pathway is frequently disabled through CDKN2A deletion, mutation, or promoter hyper-methylation, underscoring its importance in tumor suppression.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: mouse, rat\nCited Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag28927 Product name: Recombinant mouse Cdkn2a protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-168 aa of NM_001040654 Sequence: MESAADRLARAAAQGRVHDVRALLEAGVSPNAPNSFGRTPIQVMMMGNVHVAALLLNYGADSNCEDPTTFSRPVHDAAREGFLDTLVVLHGSGARLDVRDAWGRLPLDLAQERGHQDIVRYLRSAGCSLCSAGWSLCTAGNVAQTDGHSFSSSTPRALELRGQSQEQS Predict reactive species\nFull Name: cyclin-dependent kinase inhibitor 2A\nCalculated Molecular Weight: 18 kDa\nObserved Molecular Weight: 18-23 kDa\nGenBank Accession Number: NM_001040654\nGene Symbol: Cdkn2a\nGene ID (NCBI): 12578\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P51480\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46869452423337,"sku":"28416-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-28416-1-ap","provider":"Iright","version":"1.0","type":"link"}