{"product_id":"proteintech-28790-1-ap","title":"Proteintech, 28790-1-AP, Phospho-ATF2 (Thr71)\/ATF7 (Thr53) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-ATF2 (Thr71)\/ATF7 (Thr53) (28790-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-ATF2 (Thr71)\/ATF7 (Thr53) in WB, ELISA applications with reactivity to Human, Mouse samples\n28790-1-AP targets Phospho-ATF2 (Thr71)\/ATF7 (Thr53) in WB, ELISA applications and shows reactivity with Human, Mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Anisomycin treated NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:16000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nATF2, also named as CREB2 and CREBP1, contains one bZIP domain and one C2H2-type zinc finger. It belongs to the bZIP family. ATF2 binds to the cAMP-responsive element(CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. ATF2 binds DNA as a dimer and can form a homodimer in the absence of DNA. It binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity. Stress and growth factors activate ATF2 and ATF7 mainly via sequential phosphorylation of two conserved threonine residues in their activation domain. Distinct protein kinases, among which mitogen-activated protein kinases (MAPK), phosphorylate ATF2 on Thr71 and ATF7 on Thr53, resulting in transcriptional activation. The antibody recognizes ATF2 phosphorylation sites Thr71 and ATF7 phosphorylation sites Thr53.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human, Mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: activating transcription factor 2\nCalculated Molecular Weight: 209 aa, 23 kDa\nObserved Molecular Weight: 60-70 kDa\nGenBank Accession Number: BC026175\nGene Symbol: ATF2\nGene ID (NCBI): 1386\nRRID: AB_3085335\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: P15336\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887759085737,"sku":"28790-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-28790-1-ap","provider":"Iright","version":"1.0","type":"link"}