{"product_id":"proteintech-28998-1-ap","title":"Proteintech, 28998-1-AP, Phospho-LATS1 (Thr1079) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-LATS1 (Thr1079) (28998-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-LATS1 (Thr1079) in WB, ELISA applications with reactivity to human samples\n28998-1-AP targets Phospho-LATS1 (Thr1079) in WB, IHC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: Calyculin A treated HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nThe large tumour suppressor 1 (LATS1) acting as a tumour suppressor is a serine\/threonine kinase of the AGC kinase family and is found to be down-regulated in various types of human cancers. Recently, LATS1 has been identified as a central player of the emerging tumour suppressive Hippo signaling pathway. In this pathway, the MST1\/2 kinase phosphorylates activates LATS1\/2 which, together with its co-factor MOB1, subsequently phosphorylates and inhibits the YAP transcriptional factor by preventing them from translocating to the nucleus. The antibody also detects the phosphorylated at Thr1041 of the LATS2. (PMID: 32460168, PMID: 30219064,PMID: 31792377)\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nCited Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: LATS, large tumor suppressor, homolog 1 (Drosophila)\nCalculated Molecular Weight: 15 kDa, 127 kDa\nObserved Molecular Weight: 140-150 kDa\nGenBank Accession Number: BC015665\nGene Symbol: LATS1\nGene ID (NCBI): 9113\nRRID: AB_2923586\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q6PJG3\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46868898676905,"sku":"28998-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-28998-1-ap","provider":"Iright","version":"1.0","type":"link"}