{"product_id":"proteintech-29611-1-ap","title":"Proteintech, 29611-1-AP, LAMTOR1 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe LAMTOR1 (29611-1-AP) by Proteintech is a Polyclonal antibody targeting LAMTOR1 in WB, IF\/ICC, ELISA applications with reactivity to human samples\n29611-1-AP targets LAMTOR1 in WB, IF\/ICC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: A431 cells, HEK-293 cells,  HeLa cells,  HepG2 cells,  MCF-7 cells\nPositive IF\/ICC detected in: U-87 MG cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:5000-1:50000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nLAMTOR1 (Late Endosome\/Lysosome-Associated Membrane Protein 1) is a membrane protein specifically localized to the surface of late endosomes\/lysosomes and is involved in lysosomal transport and maturation. LAMTOR1 is a key component of the lysosomal articulating protein complex Ragulator, which is required for the localization of the Ragulator complex to lysosomes. LAMTOR1 is a key component of the lysosomal bridging protein complex Ragulator and is required for the localization of the Ragulator complex to the lysosome.\nLAMTOR1 is involved in autophagy, cell growth, immune regulation, cancer development, and regulatory pathways of glucose metabolism. Recent studies have shown that in calorie restriction, lithocholic acid activates AMPK through the glucose-sensing pathway ( the lysosomal pathway ) and the body senses the metabolic signals induced by calorie restriction and exerts its role in slowing down the effects of aging and prolonging the lifespan, whereas deletion of LAMTOR1 results in the inability of AMPK to be activated in order to play its role.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag31215 Product name: Recombinant human C11orf59 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 2-90 aa of BC001706 Sequence: GCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYST Predict reactive species\nFull Name: chromosome 11 open reading frame 59\nCalculated Molecular Weight: 161 aa, 18 kDa\nObserved Molecular Weight: 18 kDa\nGenBank Accession Number: BC001706\nGene Symbol: LAMTOR1\nGene ID (NCBI): 55004\nRRID: AB_3669691\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q6IAA8\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887701184681,"sku":"29611-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-29611-1-ap","provider":"Iright","version":"1.0","type":"link"}