{"product_id":"proteintech-30102-1-ap","title":"Proteintech, 30102-1-AP, MMP24 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe MMP24 (30102-1-AP) by Proteintech is a Polyclonal antibody targeting MMP24 in WB, ELISA applications with reactivity to Human, mouse, rat samples\n30102-1-AP targets MMP24 in WB, ELISA applications and shows reactivity with Human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: mouse brain tissue, rat brain tissue\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:2000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes, such as arthritis or metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP24 (MT5-MMP) is a membrane type matrix metalloproteinase attached to the cell membrane by a transmembrane domain (PMID: 30654475). MMP24 is mainly expressed in the nervous system, hippocampus, and cerebellum (PMID: 10727639,35177031). MMP24 may negatively regulate the aggressiveness of cancer cells under the stiff ECM environment during tumor progression (PMID: 32093160). MMP24 can be detected as 62-65 kDa and 55-58 kDa (PMID: 16495457,20942921,10622708).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag31597 Product name: Recombinant human mmp24 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 419-602 aa of NM_006690 Sequence: EQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNA Predict reactive species\nFull Name: matrix metallopeptidase 24 (membrane-inserted)\nCalculated Molecular Weight: 73KD\nObserved Molecular Weight: 55-58 kDa\nGenBank Accession Number: NM_006690\nGene Symbol: MMP24\nGene ID (NCBI): 10893\nRRID: AB_3086228\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q9Y5R2\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887721238697,"sku":"30102-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-30102-1-ap","provider":"Iright","version":"1.0","type":"link"}