{"product_id":"proteintech-30895-1-ap","title":"Proteintech, 30895-1-AP, Phospho-TAK1 (Ser439) Polyclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-TAK1 (Ser439) (30895-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-TAK1 (Ser439) in WB, ELISA applications with reactivity to human samples\n30895-1-AP targets Phospho-TAK1 (Ser439) in WB, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HEK-293T cells, λ phosphatase treated HEK-293T cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:500-1:1000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nMAP3K7(Mitogen-activated protein kinase kinase kinase 7) is also named as TAK1 and belongs to the MAP kinase kinase kinase subfamily. TAK1 has been identified as a crucial regulatory component of MAPK and nuclear factor-κB (NF-κB) signaling pathways, which play a key role in lipid metabolism and inflammation. Activated TAK1 then phosphorylates downstream substrates to spark the NF-κB and MAPK signaling pathways. Hence, phospho-TAK1 confers most of its regulatory functions, and inhibiting the hyperactivation of TAK1 should be a promising NASH(Nonalcoholic steatohepatitis ) therapy. (PMID: 34146477) This antibody is equivalent to Ser412 in mice.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: mitogen-activated protein kinase kinase kinase 7\nCalculated Molecular Weight: 579 aa, 64 kDa\nObserved Molecular Weight: 75-85 kDa\nGenBank Accession Number: BC017715\nGene Symbol: TAK1\nGene ID (NCBI): 6885\nRRID: AB_3669777\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: O43318\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887761412265,"sku":"30895-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-30895-1-ap","provider":"Iright","version":"1.0","type":"link"}