{"product_id":"proteintech-33685-1-ap","title":"Proteintech, 33685-1-AP, YKT6 Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe YKT6 (33685-1-AP) by Proteintech is a Polyclonal antibody targeting YKT6 in WB, IHC, IF\/ICC, ELISA applications with reactivity to human, rat samples\n33685-1-AP targets YKT6 in WB, IHC, IF\/ICC, ELISA applications and shows reactivity with human, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: A549 cells, Calu-1 cells,  HeLa cells,  rat brain tissue\nPositive IHC detected in: human ovary tumor tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\nPositive IF\/ICC detected in: A431 cells, U-251 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:6000\nImmunohistochemistry (IHC): IHC : 1:250-1:1000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:200-1:800\n\u003cb\u003eBackground Information\u003c\/b\u003e\nYKT6 is a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) that plays a central role in membrane fusion in eukaryotic cells. It is primarily localized in the cytoplasm and, through its unique dual lipidation modification (palmitoylation and farnesylation), can associate with various organelle membranes, such as the Golgi apparatus, endosomes, and vesicles. By forming stable trans-SNARE complexes with other SNARE proteins (e.g., Syntaxin and SNAP-25 family members) on target membranes, YKT6 provides the driving force for membrane fusion, thereby facilitating intracellular trafficking.\nThis protein is essential for maintaining organelle integrity, autophagy, and secretory pathways. Studies have shown that dysfunction of YKT6 is associated with various diseases, including cancer, neurodegenerative disorders, and metabolic abnormalities, making it a potential target for drug development.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: CatNo: Ag38740 Product name: Recombinant human YKT6 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 111-198 aa of BC007319 Sequence: PVGSPATIHYPALDGHLSRYQNPREADPMTKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM Predict reactive species\nFull Name: YKT6 v-SNARE homolog (S. cerevisiae)\nCalculated Molecular Weight: 22 kDa\nObserved Molecular Weight: 25 kDa\nGenBank Accession Number: BC007319\nGene Symbol: YKT6\nGene ID (NCBI): 10652\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity Purification\nUNIPROT ID: O15498\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887926137001,"sku":"33685-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-33685-1-ap","provider":"Iright","version":"1.0","type":"link"}