{"product_id":"proteintech-55218-1-ap","title":"Proteintech, 55218-1-AP, CAMK2B Polyclonal antibody","description":"Size: 20ul \/ 150ul\nThe CAMK2B (55218-1-AP) by Proteintech is a Polyclonal antibody targeting CAMK2B in WB, IHC, IF\/ICC, ELISA applications with reactivity to human, mouse, rat samples\n55218-1-AP targets CAMK2B in WB, IHC, IF\/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: A549 cells, Hela cells,  mouse brain tissue,  mouse cerebellum tissue\nPositive IHC detected in: human skeletal muscle tissue,  human brain tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\nPositive IF\/ICC detected in: HEK-293 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:6000\nImmunohistochemistry (IHC): IHC : 1:20-1:200\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:20-1:200\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCaMKII beta (Calcium\/calmodulin-dependent protein kinase type II subunit beta ), also named as CAMK2B, CAM2 or CAMKB, belongs to the protein kinase superfamily, CAMK Ser\/Thr protein kinase family and CaMK subfamily. It is a member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. It plays a distinct role in the induction of anergy in T lymphocytes, by differential regulation of IL10 and IL2 gene transcription suggesting MEF2A as a molecular target which can integrate different calcium signals (PMID:22578382). CAMK2B has 8 isoforms produced by alternative splicing with the molecular weight 50-73 kDa. This antibody is specific to CAMK2B and can recognize all the isoforms except isofom 7.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, mouse, rat\nHost \/ Isotype: Rabbit \/ IgG\nClass: Polyclonal\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: calcium\/calmodulin-dependent protein kinase II beta\nCalculated Molecular Weight: 73 kDa\nObserved Molecular Weight: 55-60 kDa\nGenBank Accession Number: NM_001220\nGene Symbol: CaMKII beta\nGene ID (NCBI): 816\nRRID: AB_11183766\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Antigen affinity purification\nUNIPROT ID: Q13554\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46885778489513,"sku":"55218-1-AP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-55218-1-ap","provider":"Iright","version":"1.0","type":"link"}