{"product_id":"proteintech-65051-1-ig","title":"Proteintech, 65051-1-Ig, Anti-Human CD107a \/ LAMP1 (H4A3)","description":"Size: 100ug \/ 500ug\nThe CD107a \/ LAMP1 (65051-1-Ig) by Proteintech is a Monoclonal antibody targeting CD107a \/ LAMP1 in WB, IF\/ICC, FC (Intra) applications with reactivity to human samples\n65051-1-Ig targets CD107a \/ LAMP1 in WB, IF\/ICC, FC (Intra) applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HEK-293 cells, HeLa cells,  Jurkat cells\nPositive IF\/ICC detected in: HeLa cells\nPositive FC (Intra) detected in: HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:8000\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:50-1:500\nFlow Cytometry (FC) (INTRA): FC (INTRA) : 0.2 ug per 10^6 cells in 100 μl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nLAMP1 (CD107a) is a heavily glycosylated membrane protein enriched in the lysosomal membrane. LAMP1 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis (PMID: 10521503). Although LAMP1 is expressed largely in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane (PMID: 16168398). Elevated LAMP1 expression at the cell surface has also been detected during platelet and granulocytic cell activation, as well as in some tumor cells (PMID: 29085473). LAMP1 functions to provide selectins with carbohydrate ligands. This protein has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells and may also play a role in tumor cell differentiation and metastasis (PMID: 18835598; 29085473; 9426697).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nCited Reactivity: human, mouse, monkey\nHost \/ Isotype: Mouse \/ IgG1, kappa\nClass: Monoclonal\nType: Antibody\nImmunogen: Human adherent peripheral blood cells Predict reactive species\nFull Name: lysosomal-associated membrane protein 1\nCalculated Molecular Weight: 45 kDa\nObserved Molecular Weight: 100-120 kDa\nGenBank Accession Number: BC006345\nGene Symbol: LAMP1\nGene ID (NCBI): 3916\nENSEMBL Gene ID: ENSG00000185896\nRRID: AB_2881467\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein G purification\nUNIPROT ID: P11279\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46887989837993,"sku":"65051-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-65051-1-ig","provider":"Iright","version":"1.0","type":"link"}