{"product_id":"proteintech-65098-1-ig","title":"Proteintech, 65098-1-Ig, Anti-Mouse LAG-3\/CD223 (C9B7W)","description":"Size: 500ug\nThe LAG-3\/CD223 (65098-1-Ig) by Proteintech is a Monoclonal antibody targeting LAG-3\/CD223 in FC applications with reactivity to mouse samples\n65098-1-Ig targets LAG-3\/CD223 in FC applications and shows reactivity with mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive FC detected in: Con-A stimulated mouse splenocytes\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFlow Cytometry (FC): FC : 0.5 ug per 10^6 cells in 100 μl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nLymphocyte activation gene 3 protein (LAG-3), also known as CD223, is a type I transmembrane protein belonging to the immunoglobulin superfamily (PMID: 1692078). It is a CD4-related molecule that binds MHC class II with high affinity (PMID: 1692078; 9159144). LAG-3 is expressed on activated T and NK cells. Besides, natural CD4(+)CD25(+) Tregs express LAG-3 upon activation (PMID: 15485628). LAG-3 negatively regulates T-cell function and homeostasis, and contributes to the suppressor activity of Tregs (PMID: 14644131; 15485628).\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: mouse\nHost \/ Isotype: Rat \/ IgG1, kappa\nClass: Monoclonal\nType: Antibody\nImmunogen: Murine CD223-Ig fusion protein Predict reactive species\nFull Name: lymphocyte-activation gene 3\nGenBank Accession Number: BC120591\nGene Symbol: CD223\nGene ID (NCBI): 16768\nRRID: AB_2918400\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Affinity purification\nUNIPROT ID: Q61790\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888098103465,"sku":"65098-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-65098-1-ig","provider":"Iright","version":"1.0","type":"link"}