{"product_id":"proteintech-65161-1-ig","title":"Proteintech, 65161-1-Ig, Anti-Human MICA\/MICB (6D4)","description":"Size: 500ug\nThe MICA\/MICB (65161-1-Ig) by Proteintech is a Monoclonal antibody targeting MICA\/MICB in FC applications with reactivity to Human samples\n65161-1-Ig targets MICA\/MICB in WB, FC applications and shows reactivity with Human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive FC detected in: HeLa cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nFlow Cytometry (FC): FC : 0.2 ug per 10^6 cells in 100 μl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nHuman MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB) (PMID: 11429322). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides (PMID: 9497295). They are expressed in intestinal epithelium and many epithelial tumors (PMID: 10359807). MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells (PMID: 10426993; 11491531). The monoclonal antibody 6D4 recognizes MICA and MICB.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human\nCited Reactivity: human\nHost \/ Isotype: Mouse \/ IgG2a, kappa\nClass: Monoclonal\nType: Antibody\nImmunogen: Transfected C1R cells expressing MICA Predict reactive species\nFull Name: MHC class I polypeptide-related sequence A\nCalculated Molecular Weight: 383 aa, 43 kDa\nGenBank Accession Number: BC016929\nGene Symbol: MICA\nGene ID (NCBI): 100507436\nRRID: AB_2881478\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Purified by protein-A affinity chromatography\nUNIPROT ID: Q29983\nStorage Buffer: PBS with 0.09% sodium azide, pH 7.3.\nStorage Conditions: Store at 2-8°C. Stable for one year after shipment.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888024735913,"sku":"65161-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-65161-1-ig","provider":"Iright","version":"1.0","type":"link"}