{"product_id":"proteintech-66045-1-ig","title":"Proteintech, 66045-1-Ig, IA-2\/PTPRN Monoclonal antibody","description":"Size: 20ul \/ 150ul\nThe IA-2\/PTPRN (66045-1-Ig) by Proteintech is a Monoclonal antibody targeting IA-2\/PTPRN in WB, IHC, IF\/ICC, ELISA applications with reactivity to human, pig, rabbit samples\n66045-1-Ig targets IA-2\/PTPRN in WB, IHC, IF\/ICC, ELISA applications and shows reactivity with human, pig, rabbit samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: pig brain tissue, human brain tissue,  rabbit brain tissue\nPositive IHC detected in: human pancreas cancer tissue, human brain tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\nPositive IF\/ICC detected in: HepG2 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\nImmunohistochemistry (IHC): IHC : 1:200-1:800\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:10-1:100\n\u003cb\u003eBackground Information\u003c\/b\u003e\nIA-2\/PTPRN  is a member of the protein tyrosine phosphatase (PTP) family, which contains a transmembrane region, an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2\/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2\/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2\/PTPRN is commonly used as a diabetes diagnosis marker.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, pig, rabbit\nHost \/ Isotype: Mouse \/ IgG3\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Ag17909 Product name: Recombinant human PTPRN protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 510-811 aa of BC007713 Sequence: WCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILKALPQ Predict reactive species\nFull Name: protein tyrosine phosphatase, receptor type, N\nCalculated Molecular Weight: 105 kDa\nObserved Molecular Weight: 60-65 kDa, 106-115 kDa\nGenBank Accession Number: BC007713\nGene Symbol: IA-2\/PTPRN\nGene ID (NCBI): 5798\nRRID: AB_11064603\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q16849\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888284717225,"sku":"66045-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-66045-1-ig","provider":"Iright","version":"1.0","type":"link"}