{"product_id":"proteintech-66082-1-ig","title":"Proteintech, 66082-1-Ig, CISD2-Specific Monoclonal antibody","description":"Size: 20ul \/ 150ul\nThe CISD2-Specific (66082-1-Ig) by Proteintech is a Monoclonal antibody targeting CISD2-Specific in WB, IHC, IF\/ICC, ELISA applications with reactivity to human,  zebrafish,  rat,  mouse samples\n66082-1-Ig targets CISD2-Specific in WB, IHC, IF\/ICC, CoIP, ELISA applications and shows reactivity with human,  zebrafish,  rat,  mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: fetal human brain tissue, MCF-7 cells,  HeLa cells,  ROS1728 cells,  RAW 264.7 cells,  zebrafish tissue\nPositive IHC detected in: human kidney tissue,  human testis tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\nPositive IF\/ICC detected in: MCF-7 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:16000\nImmunohistochemistry (IHC): IHC : 1:20-1:200\nImmunofluorescence (IF)\/ICC: IF\/ICC : 1:50-1:500\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCISD2 gene encodes a 15 kDa CDGSH iron-sulfur domain-containing protein 2, which is also named Miner1 or NAF-1, this protein was reported on endoplasmic reticulum membrane or mitochondrion outer membrane. Defects in CISD2 are the cause of Wolfram syndrome type 2 (WFS2), a rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. CISD2 regulates autophagy program by interacting BCL2, contributing to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. This monoclonal antibody is specific to CISD2 and does not cross-react with CISD1.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human, zebrafish, rat, mouse\nCited Reactivity: human, mouse\nHost \/ Isotype: Mouse \/ IgG2b\nClass: Monoclonal\nType: Antibody\nImmunogen: Fusion Protein Predict reactive species\nFull Name: CDGSH iron sulfur domain 2\nObserved Molecular Weight: 15 kDa\nGenBank Accession Number: NM_001008388\nGene Symbol: CISD2\nGene ID (NCBI): 493856\nRRID: AB_11232425\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q8N5K1\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888019329193,"sku":"66082-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-66082-1-ig","provider":"Iright","version":"1.0","type":"link"}