{"product_id":"proteintech-66280-1-ig","title":"Proteintech, 66280-1-Ig, Gelsolin Monoclonal antibody","description":"Size: 20ul \/ 150ul\nThe Gelsolin (66280-1-Ig) by Proteintech is a Monoclonal antibody targeting Gelsolin in WB, IHC, ELISA applications with reactivity to human samples\n66280-1-Ig targets Gelsolin in WB, IHC, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: human plasma tissue, U2OS cells,  A549 cells,  human plasma,  HT-29 cells\nPositive IHC detected in: human colon tissue,  human colon cancer tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:1000-1:4000\nImmunohistochemistry (IHC): IHC : 1:20-1:1000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nGelsolin (GSN) is an actin binding protein that regulates actin-severing\/depolymerizing in a calcium dependent manner, and acts as a multifunctional regulator for cell metabolism and survival. Gelsolin exists in two isoforms: a cytoplasmic gelsolin (cGSN; 80-90 kDa) and a plasma gelsolin (pGSN; 93 kDa), differing at N terminal residues. Decreased levels of pGSN are strongly associated with human diseases, such as, acute liver injury, major trauma, myocardial infarction, inflammation, lung injury, rheumatoid arthritis, hemodialysis, multiple sclerosis, Alzheimer's disease.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Mouse \/ IgA\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Ag17916 Product name: Recombinant human Gelsolin protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 433-782 aa of BC026033 Sequence: MAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAELAA Predict reactive species\nFull Name: gelsolin (amyloidosis, Finnish type)\nCalculated Molecular Weight: 782 aa, 86 kDa\nObserved Molecular Weight: 80-83 kDa\nGenBank Accession Number: BC026033\nGene Symbol: Gelsolin\nGene ID (NCBI): 2934\nRRID: AB_2881663\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Thiophilic affinity chromatograph\nUNIPROT ID: P06396\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888279900329,"sku":"66280-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-66280-1-ig","provider":"Iright","version":"1.0","type":"link"}