{"product_id":"proteintech-66571-1-ig","title":"Proteintech, 66571-1-Ig, CIN85 Monoclonal antibody","description":"Size: 20ul \/ 150ul\nThe CIN85 (66571-1-Ig) by Proteintech is a Monoclonal antibody targeting CIN85 in WB, ELISA applications with reactivity to Human, mouse, rat samples\n66571-1-Ig targets CIN85 in WB, ELISA applications and shows reactivity with Human, mouse, rat samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HL-60 cells, rat brain tissue,  K-562 cells,  PC-12 cells,  mouse brain tissue,  THP-1 cells,  Jurkat cells,  Ramos cells,  Raji cells,  Daudi cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nCIN85 is identified as a Cbl-interacting protein of 85 kDa and belongs to adaptor\/scaffold proteins. It composed of three N-terminal SH3 domains followed by a proline-rich region and a C-terminal coiled-coil region. In association with c-Cbl (Casitas B-lineage lymphoma), an E3 ubiquitin ligase.  As an adaptor protein, CIN85 is involved in Cbl-dependent EGFR internalization, intracellular receptor trafficking, sorting and degradation. Moreover, through the SH3 domains and the proline-rich region, CIN85 is implicated in many protein-protein interactions and it is found to play important roles in other processes such as apoptosis, rearrangement of actin cytoskeleton, cell adhesion, immunological synapse, cell migration and invasion.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human, mouse, rat\nHost \/ Isotype: Mouse \/ IgG1\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Ag2777 Product name: Recombinant human CIN85 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-328 aa of BC015806 Sequence: MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPP Predict reactive species\nFull Name: SH3-domain kinase binding protein 1\nCalculated Molecular Weight: 665 aa, 73 kDa\nObserved Molecular Weight: 85 kDa\nGenBank Accession Number: BC015806\nGene Symbol: SH3KBP1\/CIN85\nGene ID (NCBI): 30011\nRRID: AB_2881932\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein G purification\nUNIPROT ID: Q96B97\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888109572265,"sku":"66571-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-66571-1-ig","provider":"Iright","version":"1.0","type":"link"}