{"product_id":"proteintech-67652-1-ig","title":"Proteintech, 67652-1-Ig, TCF7L1\/TCF7L2 Monoclonal antibody","description":"Size: 20ul \/ 150ul\nThe TCF7L1\/TCF7L2 (67652-1-Ig) by Proteintech is a Monoclonal antibody targeting TCF7L1\/TCF7L2 in WB, ELISA applications with reactivity to Human, Mouse samples\n67652-1-Ig targets TCF7L1\/TCF7L2 in WB, ELISA applications and shows reactivity with Human, Mouse samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: HEK-293 cells, HeLa cells,  A431 cells,  NCCIT cells,  JAR cells,  NIH\/3T3 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:20000-1:100000\n\u003cb\u003eBackground Information\u003c\/b\u003e\nTCF7L1 is one of TCF\/LEF transcription factors that are mediators of the Wnt signaling pathway and are antagonized by the TGF-beta signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It's necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. This antibody raised against 1-200aa of human TCF7L1 can also react with TCF7L2.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human, Mouse\nHost \/ Isotype: Mouse \/ IgG2b\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Ag28954 Product name: Recombinant human TCF7L1 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-200 aa of BC058894 Sequence: MPQLGGGGGGGGGSGGGGGSSAGAAGGGDDLGANDELIPFQDEGGEEQEPSSDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQPVRDTFQKPRDYFAEVRRPQDSAFFKGPPYPGYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLSNKVPVVQHPHHMHPLTPLITYSNDH Predict reactive species\nFull Name: transcription factor 7-like 1 (T-cell specific, HMG-box)\nCalculated Molecular Weight: 63 kDa\nObserved Molecular Weight: 70 kDa\nGenBank Accession Number: BC058894\nGene Symbol: TCF7L1\nGene ID (NCBI): 83439\nRRID: AB_2882851\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: Q9HCS4\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888329773225,"sku":"67652-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-67652-1-ig","provider":"Iright","version":"1.0","type":"link"}