{"product_id":"proteintech-69006-1-ig","title":"Proteintech, 69006-1-Ig, NeutraKine® IL-12\/IL-23 p40 Mouse McAb","description":"Size: 25ug \/ 100ug\nThe NeutraKine® IL-12\/IL-23 p40 (69006-1-Ig) by Proteintech is a Monoclonal antibody targeting NeutraKine® IL-12\/IL-23 p40 in Neutralization, ELISA applications with reactivity to human samples\n69006-1-Ig targets NeutraKine® IL-12\/IL-23 p40 in Neutralization, ELISA applications and shows reactivity with human samples.\n\u003cb\u003eBackground Information\u003c\/b\u003e\nIL-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12\/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12\/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12\/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).This antibody can be used to neutralize the bioactivity of IL-12\/IL-23 p40.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nHost \/ Isotype: Mouse \/ IgG1\nClass: Monoclonal\nType: Antibody\nImmunogen: Recombinant Protein Predict reactive species\nFull Name: interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)\nCalculated Molecular Weight: 328 aa, 37 kDa\nGenBank Accession Number: BC067498\nGene Symbol: IL12B\nGene ID (NCBI): 51561,3593\nRRID: AB_2882924\nConjugate: Unconjugated\nForm: Lyophilized Powder\nPurification Method: Protein G purification\nUNIPROT ID: P29460\nStorage Buffer: Sterile PBS, pH 7.4.\nEndotoxin: \u0026lt;0.1 EU\/μg\nReconstitution: This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg\/mL in sterile H2O before use.\nStability and Storage: Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888304541865,"sku":"69006-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-69006-1-ig","provider":"Iright","version":"1.0","type":"link"}