{"product_id":"proteintech-69010-1-ig","title":"Proteintech, 69010-1-Ig, NeutraKine® Noggin Monoclonal antibody","description":"Size: 25ug \/ 100ug\nThe NeutraKine® Noggin (69010-1-Ig) by Proteintech is a Monoclonal antibody targeting NeutraKine® Noggin in ELISA, Neutralization applications with reactivity to Human samples\n69010-1-Ig targets NeutraKine® Noggin in ELISA, Neutralization applications and shows reactivity with Human samples.\n\u003cb\u003eBackground Information\u003c\/b\u003e\nNoggin is an extracellular polypeptide acting as an antagonist of bone morphogenetic proteins (BMPs) regulating embryonal development. Noggin inhibits activity of BMP-2, -4, -7, -13, and -14. Noggin is present extracellularly in the matrix or retained at the cell surface via interaction with heparin sulfate proteoglycans. In early development stages, Noggin is produced by the Spemann organizer, allowing dorsal-ventral patterning of BMPs (PMID: 8752214). Subsequently, Noggin is expressed by the notochord regulating BMP-4 signaling in neurogenesis. Additionally, Noggin is present during development in the dermal papilla, connective tissue of the hair follicle, lens, retina, and periocular mesenchyme, as well as in the mesoderm lineage regulating development of the bone, cartilage, and muscles.This antibody can be used to neutralize the bioactivity of Noggin.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human\nHost \/ Isotype: Mouse \/ IgG1\nClass: Monoclonal\nType: Antibody\nImmunogen: CatNo: Product name: HumanKine® recombinant human Noggin protein Source: -derived, Tag: Domain: of Sequence: Predict reactive species\nFull Name: noggin\nGene Symbol: Noggin\nGene ID (NCBI): 9241\nRRID: AB_2882928\nConjugate: Unconjugated\nForm: Lyophilized Powder\nPurification Method: Protein G purification\nUNIPROT ID: Q13253\nStorage Buffer: Sterile PBS, pH 7.4.\nEndotoxin: \u0026lt;0.1 EU\/μg\nReconstitution: This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg\/mL in sterile H2O before use.\nStability and Storage: Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888304771241,"sku":"69010-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-69010-1-ig","provider":"Iright","version":"1.0","type":"link"}