{"product_id":"proteintech-69521-1-ig","title":"Proteintech, 69521-1-Ig, NeutraControl IL-17A Monoclonal antibody","description":"Size: 100ug\nThe NeutraControl IL-17A (69521-1-Ig) by Proteintech is a Monoclonal antibody targeting NeutraControl IL-17A in ELISA, Non-Neutralization applications with reactivity to Human samples\n69521-1-Ig targets  IL-17A in ELISA, Non-Neutralization applications and shows reactivity with Human samples.\n\u003cb\u003eBackground Information\u003c\/b\u003e\nIL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2\/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.This antibody is a neutralizing control antibody for IL-17A,  the immunogen is the same as Neutrakine 69021-1-Ig but could not neutralize human IL-17A.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: Human\nHost \/ Isotype: Mouse \/ IgG1\nClass: Monoclonal\nType: Antibody\nImmunogen: RecombinantProtein Predict reactive species\nFull Name: interleukin 17A\nGene Symbol: IL-17A\nGene ID (NCBI): 3605\nENSEMBL Gene ID: ENSG00000112115\nRRID: AB_2918855\nConjugate: Unconjugated\nForm: Lyophilized Powder\nPurification Method: Protein G purification\nUNIPROT ID: Q16552\nStorage Buffer: Sterile PBS, pH 7.4.\nEndotoxin: \u0026lt;0.1 EU\/μg\nReconstitution: This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg\/mL in sterile H2O before use.\nStability and Storage: Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888303132841,"sku":"69521-1-Ig","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-69521-1-ig","provider":"Iright","version":"1.0","type":"link"}