{"product_id":"proteintech-80115-1-rr","title":"Proteintech, 80115-1-RR, Phospho-STAT5A (Tyr694)\/STAT5B (Tyr699) Recombinant monoclonal antibody","description":"Size: 20ul \/ 100ul\nThe Phospho-STAT5A (Tyr694)\/STAT5B (Tyr699) (80115-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-STAT5A (Tyr694)\/STAT5B (Tyr699) in WB, FC (Intra), ELISA applications with reactivity to human samples\n80115-1-RR targets Phospho-STAT5A (Tyr694)\/STAT5B (Tyr699) in WB, IHC, FC (Intra), ELISA applications and shows reactivity with human samples.\n\u003cb\u003eTested Applications\u003c\/b\u003e\nPositive WB detected in: GM-CSF treated TF-1 cells\nPositive FC (Intra) detected in: GM-CSF treated TF-1 cells\n\u003cb\u003eRecommended dilution\u003c\/b\u003e\nWestern Blot (WB): WB : 1:2000-1:10000\nFlow Cytometry (FC) (INTRA): FC (INTRA) : 0.06 ug per 10^6 cells in a 100 µl suspension\n\u003cb\u003eBackground Information\u003c\/b\u003e\nSTAT5A, also named as STAT5, belongs to the transcription factor STAT family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5A is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different GHs. Phosphorylation at Tyr694 is obligatory for Stat5 activation. Activation of STAT5A in myeloma and lymphoma associated with a TEL\/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of human STAT5A is found to induce the expression of BCL2L1\/BCL-X(L), which suggests the antiapoptotic function of STAT5A in cells.\n\u003cb\u003eSpecification\u003c\/b\u003e\nTested Reactivity: human\nCited Reactivity: human, mouse\nHost \/ Isotype: Rabbit \/ IgG\nClass: Recombinant\nType: Antibody\nImmunogen: Peptide Predict reactive species\nFull Name: signal transducer and activator of transcription 5A\nCalculated Molecular Weight: 794 aa, 92 kDa\nObserved Molecular Weight: 90-95 kDa\nGenBank Accession Number: BC027036\nGene Symbol: STAT5A\nGene ID (NCBI): 6776\nRRID: AB_2918866\nConjugate: Unconjugated\nForm: Liquid\nPurification Method: Protein A purification\nUNIPROT ID: P42229\nStorage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.\nStorage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.","brand":"Proteintech","offers":[{"title":"Default Title","offer_id":46888529756329,"sku":"80115-1-RR","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/proteintech-80115-1-rr","provider":"Iright","version":"1.0","type":"link"}